- With chronic high circulating blood glucose levels, some glucose binds irreversibly onto the red blood cells (RBC) and remains there for the life of the cell. The average life span of an RBC is 120 days. The measurement of glycosylated hemoglobin (HbA1c), which detects glucose binding on the RBC membrane, is expressed as a percent. One of the problems in diabetes is that muscle and adipose cells may be unable to transport glucose across cell membranes. Glucose does not bind onto platelets in diabetes mellitus.
Saturday, November 22, 2008
Where does Glucose bind irreversably as a result of chronic hyperglycemia?
- With chronic high circulating blood glucose levels, some glucose binds irreversibly onto the red blood cells (RBC) and remains there for the life of the cell. The average life span of an RBC is 120 days. The measurement of glycosylated hemoglobin (HbA1c), which detects glucose binding on the RBC membrane, is expressed as a percent. One of the problems in diabetes is that muscle and adipose cells may be unable to transport glucose across cell membranes. Glucose does not bind onto platelets in diabetes mellitus.
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